About DIC
  • DIC and underlying diseases
    • Infection-associated DIC
  • About Coagulation Cascades

DIC and underlying diseases

DIC is caused by a variety of underlying diseases and occurs mainly in patients having infections, leukemia, solid cancers, or obstetrical diseases.

Infection-associated DIC
  • Pathologic features
  • Treatment
  • Professor Satoshi Gando, Acute and Critical Care Medicine, Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine


In 1997, a survey on the incidence of DIC and underlying diseases was carried out in 652 divisions and departments (internal medicine, surgery, pediatrics, obstetrics and gynecology, intensive care, and emergency medical care) of university hospitals in Japan1).

DIC occurred in 2,193 patients in these institutions in 1997. The number of patients having infections (including sepsis) and hematologic tumors (including leukemia) accounted for 28% and 23%, respectively,.

Underlying diseases in DIC patients

1)Masao Nakagawa: Modified from a research report on the incidence of disseminated intravascular coagulation (DIC) and underlying diseases in Japan
The Committee on Abnormal Blood Coagulation, Study Group on Specified Diseases and Blood Diseases, Ministry of Health, Labour and Welfare. Research report published in Fiscal Year 1998; 57-64, 1999