ABOUT Recomodulin(ART-123)
  • History of Recomodulin
  • Mechanism of Action
  • The results of the Japanese Phase III clinical study
  • Press release

Mechanism of Action

Recomodulin™(ART-123) activates protein C through its binding to thrombin.

ART-123 is a soluble recombinant human thrombomodulin. ART-123 inhibits the coagulation process by accelerating the activation of protein C by thrombin.

The activated protein C (APC) degrades Factor Va and Factor VIIIa, both key factors in the clotting cascade, using protein S as a coenzyme, and inhibits coagulation by reducing thrombin generation.

Blood coagulation regulation mediated by Recomodulin™(ART-123) through activation of protein C